Protein function prediction using the Protein Link EXplorer (PLEX)
نویسندگان
چکیده
منابع مشابه
Protein function prediction using the Protein Link EXplorer (PLEX)
UNLABELLED We introduce the Protein Link EXplorer (PLEX), a web-based environment that allows the construction of a phylogenetic profile for any given amino acid sequence, and its comparison with profiles of approximately 350,000 predicted genes from 89 genomes, as a means of interactively identifying functionally linked genes and predicting protein function. PLEX can be searched iteratively an...
متن کاملPrediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks
Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...
متن کاملPrediction of Protein Function Using Protein-Protein Interaction Data
Assigning functions to novel proteins is one of the most important problems in the postgenomic era. Several approaches have been applied to this problem, including the analysis of gene expression patterns, phylogenetic profiles, protein fusions, and protein-protein interactions. In this paper, we develop a novel approach that employs the theory of Markov random fields to infer a protein's funct...
متن کاملProtein Function Prediction Using Protein–Protein Interaction Networks
Proteins perform biological functions by participating in a large number of interactions, ranging from transient interactions in signaling pathways to permanent interactions within stable complexes. Studies have shown that the immediate interaction neighborhood of a protein can be used to infer its functions. While using only such direct interactions limits prediction coverage, extending the in...
متن کاملLink Prediction in Protein-Protein Networks: Survey
Protein networks have a great importance in biological activities. ProteinProtein interaction occurs when two or more proteins interact together to carry out some biological activities. For example signals from the exterior of a cell are mediated to the interior through these interactions. Identification of these interaction have a great significance in understanding complex diseases and also f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti313